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[Animal Modeling] - Animal Model of Hypertensive Liver Yang Hyperactivity Syndrome with Shuangshen Shuangjia and Guanfuzi Tang

[Animal Modeling] - Animal Model of Hypertensive Liver Yang Hyperactivity Syndrome with Shuangshen Shuangjia and Guanfuzi Tang

Adult rats were anesthetized, and a longitudinal incision was made in the middle of the abdomen. The bilateral renal arteries were bluntly separated. Silver clips with an inner diameter of 0.2-0.23mm were used to clamp the initial part of the bilater...

2023-09-13
【Animal Modeling】 - A Rat Model of Non steroidal Anti inflammatory Drug Induced Gastric Mucosal Injury

【Animal Modeling】 - A Rat Model of Non steroidal Anti inflammatory Drug Induced Gastric Mucosal Injury

After fasting for 18 hours and water deprivation for 1 hour, rats were gavaged with 0.1% indomethacin 5ml/kg. The control group was given an equal amount of physiological saline...

2023-09-13
【Animal Modeling】 - Transgenic Mouse Psoriasis Model

【Animal Modeling】 - Transgenic Mouse Psoriasis Model

Animal models related to the Stat3 pathway: Sano S et al. continuously activated the Star3 pathway by inserting the KRT5 promoter into basal keratinocytes, leading to spontaneous or psoriatic skin lesions in response to external damage, such as kerat...

2023-09-13
【Animal Modeling】 - Reflux Gastritis Model

【Animal Modeling】 - Reflux Gastritis Model

Model rats were anesthetized by intraperitoneal injection of pentobarbital at a dose of 30mg/kg, followed by skin disinfection with iodine. After laparotomy, the stomach and upper jejunum were exposed, and the anterior stomach was fixed together with...

2023-09-13
【Animal Modeling】 - Induced Psoriasis Animal Model

【Animal Modeling】 - Induced Psoriasis Animal Model

Application of propranolol to create a guinea pig ear psoriasis model. This model is commonly used in China. Huang et al. applied 5% propranolol to the ears of guinea pigs (350-400g) (0.3g of drug per cm2) twice a day for 2 weeks, while using 1% dini...

2023-09-13
【 Animal modeling 】 -2,4-dinitrochlorobenzene induced colitis in rats

【 Animal modeling 】 -2,4-dinitrochlorobenzene induced colitis in rats

Animal modeling materials: Adult rats, male and female, weighing 200-250g; Drugs: 2,4-dinitrochlorobenzene, acetone, acetic acid, ethanol; Instrument: 3mm diameter nylon catheter...

2023-09-12
【 Animal Modeling 】 - Animal Model of Spleen and Stomach Deficiency Cold Syndrome Using Vinegar Method

【 Animal Modeling 】 - Animal Model of Spleen and Stomach Deficiency Cold Syndrome Using Vinegar Method

Reproduction method: Adult rats were gavaged with 4 ℃ vinegar daily, with a volume of 10ml/kg body weight for 10 consecutive days. During this period, observe changes in animal appearance and behavior, weight, food intake, and water intake. On the da...

2023-09-12
【 Animal Modeling 】 - X-Ray irradiation on an animal model of spleen qi deficiency syndrome

【 Animal Modeling 】 - X-Ray irradiation on an animal model of spleen qi deficiency syndrome

Reproduction method: Adult rats were raised in a single cage and subjected to external abdominal irradiation at a dose of 250 rad/min. The first dose was followed by a second dose of enhancement 7 days after the first dose. The changes in food intake...

2023-09-12
【Animal Modeling】 - Mice with Toll like Receptor Deficiency

【Animal Modeling】 - Mice with Toll like Receptor Deficiency

Toll like receptor 2 gene knockout mice. In Toll like receptor 2 gene knockout mice, homozygotes can survive with normal appearance and behavior. Macrophages from mouse bone marrow cannot stimulate immune responses to lipoproteins of Borrelia burgdor...

2023-09-12
【 Animal Modeling 】 - Animal model of spleen qi deficiency syndrome caused by hunger and satiety disorders and excessive fatigue

【 Animal Modeling 】 - Animal model of spleen qi deficiency syndrome caused by hunger and satiety disorders and excessive fatigue

Reproduction method: Adult rats were raised in a single cage, and the experimental rat cage was fixed to the oscillator using a tray. The oscillator was controlled by a relay to stop for 10 minutes every 20 minutes of vibration, with an average of 10...

2023-09-12
[Animal modeling] - T cell deficient mice

[Animal modeling] - T cell deficient mice

The homozygous CD4 antigen knockout mice cannot express CD4 on the cell surface. CD8+T cells and myeloid components develop normally. This indicates that expression in ancestral cells and CD4+CD8+thymocytes is not necessary. The antiviral activity of...

2023-09-12
【 Animal Modeling 】 - Animal Model of Spleen Qi Deficiency Syndrome with Diarrhea and Excessive Fatigue

【 Animal Modeling 】 - Animal Model of Spleen Qi Deficiency Syndrome with Diarrhea and Excessive Fatigue

Reproduction method: Adult rats were raised in a single cage and given a sufficient amount of medicated feed (rhubarb, mirabilite, and standard feed materials were evenly mixed in a ratio of 0.85:0.15:9.0 to make medicated feed, with 0.1g of raw medi...

2023-09-12
【Animal Modeling】 - Immunomodulatory Factor Deficiency Mouse Model

【Animal Modeling】 - Immunomodulatory Factor Deficiency Mouse Model

Gene knockout mice with B cell defects. In B cell deficient Igh-6 gene knockout mice, homozygotes lack mature B cells and cannot express membrane bound IgM. This mouse is mainly used to study the function of B cells in the immune system. For example,...

2023-09-12
【 Animal Modeling 】 - Animal Model of Spleen Qi Deficiency Syndrome with Dietary Preference Method

【 Animal Modeling 】 - Animal Model of Spleen Qi Deficiency Syndrome with Dietary Preference Method

Reproduction method: Adult rats were orally gavaged with Shanxi white vinegar at a dose of 10ml/kg body weight for 10 consecutive days. Observe changes in food intake, spontaneous activity, body weight, rectal temperature, stool characteristics, and ...

2023-09-12
【Animal Modeling】-Evaluation of the Operational Effect of Animal Nasal Aerosol Exposure Device

【Animal Modeling】-Evaluation of the Operational Effect of Animal Nasal Aerosol Exposure Device

The purpose of this study is to investigate whether the animal nasal aerosol exposure device can operate normally and generate aerosol particles with a specific particle size, and to explore the air tightness, distribution uniformity and disinfection...

2023-09-11
【Animal Modeling】-Preliminary study on the mechanism of hypoxic preconditioning reducing the susceptibility to epilepsy and its brain protective effect in rats

【Animal Modeling】-Preliminary study on the mechanism of hypoxic preconditioning reducing the susceptibility to epilepsy and its brain protective effect in rats

To preliminarily investigate the effect of intermittent hypoxic preconditioning on epileptic seizures in rats induced by lithium chloride and pilocarpine and its brain protective mechanism...

2023-09-11