【Animal Modeling】-Lentivirus-mediated shRNA targeting survivin gene inhibits the growth of endometrium in the abdominal cavity of nude mice

To study the effect of lentivirus-mediated survivin gene-specific short hairpin RNA (shRNA) on the growth of human endometrium in the peritoneal cavity of nude mice...

2022-07-25

【Animal Modeling】-miR-20b inhibits airway inflammation in asthmatic mice

To investigate the effect of miR-20b on airway inflammation in asthmatic mice...

2022-07-25

【Animal Modeling】-Regulatory T cell therapy for experimental mouse polymyositis and its mechanism

To investigate the therapeutic value and mechanism of CD4+ CD25+ Foxp3+ Treg cells in experimental autoimmune myositis (EAM) mice...

2022-07-25

【Animal modeling】-Edaravone can reduce oxidative stress and delay myocardial fibrosis in rats

To investigate the effect of edaravone on reducing oxidative stress and anti-myocardial fibrosis...

2022-07-25

【Animal modeling】-Pathological changes of amyloidosis and cerebrovascular disease in Alzheimer\'s disease rats

To investigate the pathological changes of brain tissue of amyloidosis cerebrovascular lesions on the basis of establishing an experimental rat model of Alzheimer\\\'s disease...

2022-07-25

【Animal modeling】-Recombinant lentivirus-mediated LXRα RNA interference improves the function of rat fatty liver donor liver transplantation

To investigate the effect and mechanism of LXRα RNA interference (RNAi) in improving liver function in rats with fatty liver after liver transplantation...

2022-07-25

【Animal modeling】-Effect of acute incision pain on the expression of connexin Cx43 in the dorsal horn of spinal cord in rats

To observe the effect of acute incision pain on the expression of connexin43 (Cx43) in the dorsal horn of rat spinal cord...

2022-07-25

【Animal Modeling】-Determination of blood concentration of carbamazepine in rats after administration and its NMR metabolomics analysis

To analyze the effect of carbamazepine on the serum metabolome of rats after intragastric administration using nuclear magnetic resonance (NMR)-based metabolomics technology...

2022-07-25

【Animal modeling】-Immune protection of Sap2 protein and dendritic cells against systemic Candida albicans infection

Mice were immunized with recombinant protein and dendritic cells (DC) to observe the immune protection effect on systemic Candida albicans...

2022-07-25

【Animal modeling】-Effect of deoxycholic acid on the growth of ileal organoids in C57BL/6 mice

To investigate the effects of chronic intermittent hypoxia-induced inflammatory factors and reoxygenation on glucose metabolism and skeletal muscle glucose transporter 4 (GLUT-4) expression in rats...

2022-07-25

【Animal modeling】-Expression and significance of basic leucine zipper transcription factor ATF-like protein in kidney tissue of lupus mice

To investigate the expression and clinical significance of basic leucine zipper transcription factor ATF-like protein in kidney tissue of lupus mice...

2022-07-21

【Animal modeling】-Effect of Ghrelin on the expression of DKK-1 in the hippocampus and learning and memory function of diabetic rats

To observe the expression changes of Ghrelin on DKK-1 and WNT signaling pathways in diabetic rats, and to explore the mechanism involved in learning and memory function...

2022-07-21

【Animal modeling】-Protective effect of piperphentonamine hydrochloride on gentamicin-induced hearing loss in guinea pigs

To observe the relationship between guinea pig cochlear autophagy-related proteins beclin1 and LC3, Na+-K+-2Cl- co-transporter (NKCC1) mRNA, endothelin (ET) expression and cochlear gentamicin (GM) injury and piperphentonamine hydrochloride (PPTA) pro...

2022-07-21

【Animal Modeling】-Effect of bis(2-ethyl)hexyl phthalate exposure during pregnancy on the growth and development of mouse placenta

To observe the effects of DEHP exposure on placental growth and development, the number of uNK cells at the maternal-fetal interface and angiogenesis in mice by exposure to di(2-ethyl)hexyl phthalate (DEHP) during pregnancy...

2022-07-21

【Animal modeling】-Mechanism of transient receptor potential channel C1 in airway remodeling in guinea pig asthma and the intervention effect of budesonide

To explore the mechanism of TRPC1 ion channel in the evolution of airway remodeling and the intervention effect of budesonide by interfering with the expression of transient receptor potential channel C1 (TRPC1)...

2022-07-21

【Animal modeling】-Protective effect of Nrf2 antioxidant pathway in CCl4-induced acute liver injury in rats

To study the protective effect of Nrf2 oxidative damage pathway in CCl4-induced acute liver injury in rats...

2022-07-21