[Animal modeling] - Interventional effect and possible mechanism of resveratrol on premature ovarian failure in mice

To observe the intervention effect of resveratrol on premature ovarian failure in mice and elucidate its possible mechanism...

2023-03-21

[Animal modeling] - protective effect of miR-214 on postoperative neuronal damage in propofol anesthetized rats

To explore the effects of different exercise modes on skeletal muscle growth factors MSTN and IGF1 in rats, and to provide theoretical basis for selecting appropriate exercise modes to improve skeletal muscle function...

2023-03-21

[Animal modeling] - Effect of arginine vasopressin 1b receptor knockout on anxiety and social behavior in female rats

To investigate the effects of arginine vasopressin 1b receptor gene knockout on plasma corticosterone content, anxiety, and social behavior in female rats...

2023-03-21

【Animal modeling】-Preparation of rat thoracic aortic vascular smooth muscle cells by an improved two-step compound enzyme digestion method

This paper reports an improved method for the isolation of rat thoracic aortic vascular smooth muscle cells based on compound enzymatic digestion...

2023-03-20

[Animal Modeling] - Study on the Mechanism of Intermittent Fasting in Improving Metabolic Disorders Induced by Olanzapine in Mice

To investigate the protective effect and mechanism of intermittent fasting on metabolic disorders induced by olanzapine in mice...

2023-03-20

[Animal modeling] - Inhibition of miR-146b-5p expression in situ improves renal fibrosis in UUO mice

To investigate the expression of miR-146b-5p in a mouse model of renal fibrosis, and to investigate the effect of knocking down miR-146b-5p in vivo on renal injury and fibrosis in mice...

2023-03-20

[Animal Modeling] Experimental Study on the Effect of MTS1/2 Inhibitor on the Repair of Spinal Cord Injury in Rats

To investigate the effects of MST1/2 inhibitors on the expression of Yes related protein YAP, nerve growth related protein 43, glial fibrillary protein GFAP, apoptosis factor Caspase 3, and motor function recovery after spinal cord injury in rats...

2023-03-20

[Animal Modeling] - Lingzhu Tusi Pill Inhibits IKK β/ NF- κ B/MCP-1 pathway reduces adriamycin induced renal proteinuria in rats

To investigate the effect and mechanism of Lingzhu Tusi Pill on adriamycin induced nephrotic proteinuria...

2023-03-20

【Animal Modeling】-Lactobacillus rhamnosus culture supernatant prevents Escherichia coli meningitis by inhibiting NF-κB pathway

To investigate whether Lactobacillus rhamnosus supernatant (LGG-CM) can block bacterial meningitis caused by E. coli K1 strain by inhibiting NF-κB pathway in vitro...

2023-03-17

【Animal modeling】-The role of CaN-NFATc3 pathway in restenosis after balloon dilation of abdominal aorta in rats

To study the role of calcineurin (CaN) and its downstream activated T cell nuclear factor (NFATc3) in restenosis after balloon dilatation, and to provide a new theoretical basis for the prevention and treatment of vascular restenosis...

2023-03-17

【Animal Modeling】-Effect of long-term high-protein diet on hepatic steatosis and fat accumulation in OVX mice

To investigate the effect of long-term high-protein diet on liver and adipose tissue in ovariectomized mice and the effect of glucagon-like peptide-1...

2023-03-16

【Animal modeling】Effect of -17βestradiol on propofol-induced apoptosis of cortical neurons

To investigate the effect and mechanism of 17β-estradiol on the apoptosis of primary cultured cortical neurons induced by propofol...

2023-03-16

【Animal Modeling】-Effects of electroacupuncture on synaptic plasticity and microglia polarization in rats with cerebral ischemia

To investigate synaptic plasticity and microglial polarization in rats with focal cerebral ischemia by electroacupuncture, and to detect the expression of miR-21/signal transducer and activator of transcription 3 (STAT3) pathway...

2023-03-16

【Animal Modeling】-Proliferation of umbilical cord mesenchymal stem cells on dairy bovine mammary epithelial cells under serum-free co-culture conditions

To investigate the proliferation effect of umbilical cord mesenchymal stem cells on dairy bovine mammary epithelial cells under serum-free co-culture conditions...

2023-03-16

【Animal modeling】-Effect of low selenium diet on the expressions of CD163, CD206 and CCR7 in the liver and kidney of rats

To investigate the effect of low selenium diet on liver and kidney in rats, and the role of macrophage polarization to M1 and M2 in liver and kidney fibrosis...

2023-03-16

【Animal modeling】The effect of -1α,25(OH)2D3 on the expression of lubricin in rat articular chondrocytes

To investigate the effect of 1α,25(OH)2D3 on the synthesis and secretion of lubricin in chondrocytes at the cellular level...

2023-03-16