【Animal Modeling】-The role of nerve growth factor antibody in mouse knee osteoarthritis pain model

Knee osteoarthritis (OA) is a common chronic degenerative disease characterized by degeneration of articular cartilage components, synovitis, subchondral bone remodeling and joint muscle atrophy...

2021-02-02

[Animal modeling]-Optimization of the dose-effect relationship between N-ethyl-N-nitrosourea and cyclophosphamide in the Pig-a gene mutation test in rats

To study the effect of different doses of N-ethyl-N-nitrosourea (ENU) and cyclophosphamide (CP) on the deletion rate of ankyrin CD59 on the peripheral red blood cell surface of SD rats, and optimize the detection method of Pig-a gene mutation test...

2021-02-02

[Animal Modeling]-The damage effect of Busulfan on the function of hematopoietic stem cells in mice

Explore the effects of various administration methods on the function of hematopoietic stem cells in mice...

2021-02-02

【Animal Modeling】-The effect of vitamin D deficiency on the pathogenesis of spontaneous diabetic rats

To explore the effect of vitamin D deficiency on the etiology of spontaneous diabetic rats...

2021-02-02

[Animal Modeling] The effect of botulinum toxin type A heavy chain intervention on the expression of growth-related proteins after spinal cord injury in rats

To explore the effect of artificially recombined botulinum toxin type A heavy chain (BoNT/A heavy chain) on the expression of local growth-related proteins in rats with spinal cord injury, and provide a basis for elucidating its mechanism...

2021-02-02

【Animal Modeling】-The effect of high-fat feed feeding time on type 2 diabetic nephropathy rat model

How to investigate the effect of feeding time on the blood glucose, insulin resistance index (HOMA-IR) and urinary albumin excretion rate (UAER) of a variety of high-fat diets in type 2 diabetic nephropathy rat models?...

2021-02-02

Effect of Inhibiting Peripheral Neuron PAR2-PKA/PKCε Pathway on Pain Threshold in Rats with Pain Transformation Model

To explore the role of peripheral neuroprotease activated receptor 2-protein kinase A/protein kinase Cε (PAR2-PKA/PKCε) pathway in pain changes, and possible solutions for simultaneous intervention in acute and chronic pain...

2021-02-02

Cysteinyl leukotriene receptor antagonist reduces global cerebral ischemia-reperfusion injury in Mongolian gerbils by down-regulating autophagy

To explore the protective effect and mechanism of cysteinyl leukotriene receptor antagonists (Plukast, HAMI 3379) on global cerebral ischemia-reperfusion injury in Mongolian gerbils...

2021-02-02

Compound Zhenzhu Tiaozhi Capsule Regulates MEKK2-Wnt Coupling and Antagonizes β-catenin Ubiquitination Improves Glucocorticoid Osteoporosis in Rats

　　Through the intervention of Zhenzhu Tiaozhi Capsule (FTZ), a compound that antagonizes β-catenin ubiquitination and bone and cell changes, explore the regulation of mitogen-activated protein kinase 2-Wnt...

2021-02-02

[Animal Modeling]-Correlation between cognitive development and hippocampal dopamine and dihydroxyphenylacetic acid in 80-day-old pups from pregnant rats

　　To investigate the effects of cognitive development and dopamine (DA) and dopamine (3,4-dihydroxyphenylacetic acid, DOPAC) levels in hippocampus of 80-day-old pups born from pregnant rats with fear of injury, and explore the correlation between the...

2021-02-01

【Animal Modeling】-Curcumin\'s chemical intervention effect and mechanism analysis on N-methylnitrosourea-induced bladder cancer in rats

To analyze the chemical intervention and mechanism of curcumin in the rat model of bladder cancer induced by N-methylnitrosourea (MNU)...

2021-02-01

[Animal Modeling]-Metabonomics study of changes in metabolic pathways during the immunosuppressive effect of cyclophosphamide on mice

Using metabonomics method to study the changes of metabolic pathways during the immunosuppressive effect of cyclophosphamide on mice...

2021-02-01

【Animal Modeling】-Analysis of Right Heart Function in Rats with Alkaline Pulmonary Hypertension

Study the relationship between changes in pulmonary artery pressure and changes in right ventricular function...

2021-02-01

【Animal Modeling】-The effect of PM2.5 on rat uterine tissue morphology and oxidative stress

To explore the effects of PM2.5 on the physiology and related biochemical stress of rat uterine tissue...

2021-02-01

【Animal Modeling】The effect of -20Hz square wave and sine wave frequency flash on the eyeball development of guinea pigs

To evaluate the effects of continuous high frequency sine wave and square wave stroboscopic on emmetropia and eye development in guinea pigs...

2021-02-01

【Animal Modeling】-The effect of miR-424 on the migration and invasion of non-small cell lung cancer cell line A549

To investigate the effect of miR-424 on the migration and infiltration of non-small cell lung cancer A549 cells...

2021-02-01