【Animal Modeling】-Establishment of a rat model of myocardial cell mitochondrial injury induced by bupivacaine

To observe the changes of mitochondrial morphology and reactive oxygen species generation in bupivacaine cardiomyocytes under electrical stimulation, and to explore the establishment of an ideal rat cardiomyocyte model of bupivacaine poisoning...

2022-08-29

【Animal modeling】-Construct a rat COPD-OSAHS overlap syndrome model by smoking and intermittent hypoxia

To construct a rat model of COPD-OSAHS overlap syndrome (OS), and to provide a feasible means and experimental platform for basic research on OS...

2022-08-29

【Animal Modeling】-Establishment of gastric cancer metastasis model based on clinical tumor specimens

To establish a gastric cancer metastasis model based on clinical tumor specimens, and to provide an individualized animal model for the study of gastric cancer metastasis...

2022-08-29

【Animal Modeling】-Establishment of a rat model of fear and stress and analysis of its visual cognitive effect

To construct a rat model of different degrees of fear stress, and to explore the effect of fear stress on the visual cognitive ability of LE rats...

2022-08-29

【Animal modeling】-Establishment and evaluation of a rat model of visceral hypersensitivity induced by foot shock

To establish a rat model of visceral hypersensitivity by plantar electric shock, and to evaluate its effectiveness and advantages...

2022-08-29

【Animal modeling】-Comparison of BALB/c mice model of bronchial asthma induced by different doses of ovalbumin

To investigate the effects of different doses of ovalbumin on serum IgE, IL-4, IFNγ levels, bronchoalveolar lavage fluid eosinophil counts and lung histopathology in BALB/c mice model of bronchial asthma, and to preliminarily determine the appropriat...

2022-08-29

【Animal Modeling】-Construction of an experimental autoimmune myasthenia gravis mouse model using the black-spotted double-fin electric ray

To establish an experimental autoimmune myasthenia gravis animal model that meets international preclinical experimental standards...

2022-08-29

【Animal Modeling】-Expression of Thrombomodulin in Rat Model of Deep Vein Thrombosis and Its Significance

To observe the expression and significance of thrombomodulin (TM) in the natural evolution process of deep vein thrombosis (DVT) formation and regression in rats...

2022-08-29

【Animal Modeling】-Establishment of a nude mouse model of colon cancer liver metastasis

To construct a colon cancer liver metastasis model with high metastasis rate, simple operation and reliable results for experimental research on the prevention and treatment of colon cancer metastasis...

2022-08-29

【Animal modeling】-Hpd gene modification to prepare hypertyrosinemia type III Bama minipig model

To use CRISPR/Cas9 technology to knock out 4-hydroxyphenylpyruvate oxidase in Bama minipig to create a hypertyrosinemia type III Bama minipig model...

2022-08-29

【Animal Modeling】-Establishment and treatment of human xenograft nude mouse model of prostate cancer

To establish a human-derived xenograft model of prostate cancer and evaluate the anti-tumor effect of different treatment regimens...

2022-08-29

【Animal modeling】-Comparison of insulin resistance atherosclerosis models between white-haired black-eyed rabbits and Japanese big-eared white rabbits

To investigate the phenotypic differences and pathological mechanisms of insulin-resistant atherosclerotic models in white-haired black-eyed (WHBE) rabbits and Japanese white-eared white (JW) rabbits...

2022-08-29

【Animal modeling】-Tail vein injection of M1 cells to construct BALB/c nude mouse model of myeloid leukemia

To construct M1 leukemia model using BALB/c nude mice...

2022-08-29

【Animal Modeling】-Establishment and evaluation of a mouse model of endogenous infection induced by intestinal dissemination

To establish a mouse model of endogenous infection induced by intestinal dissemination, and to provide a reliable experimental model for studying the mechanism of intestinal microecology and endogenous infection...

2022-08-29

【Animal Modeling】-Establishment and preliminary analysis of the cynomolgus monkey model of hyperlipidemia

To establish a hyperlipidemia cynomolgus monkey model with similar characteristics of human diseases, and to provide an ideal animal model for the development of lipid-lowering drugs (especially biological lipid-lowering drugs)...

2022-08-29

【Animal Modeling】-Analysis of Mozart\'s K448 Sonata High-frequency Sound Wave on Intervention and Treatment of Depression Model in Mice

To establish a depression model in C57BL/6 mice, and to preliminarily explore the effect of high-frequency sound waves in Mozart\'s K448 sonata on improving depressive symptoms in C57BL/6 mice...

2022-08-26